Retinoids Retinoids, a class of vitamin-A derivatives, easily get the gold star for their tried-and-true anti-aging benefits. "Topical retinoids have the strongest and best evidence for slowing down collagen breakdown in many different ways," says MacGregor. And as if that weren't enough, they also stimulate the production of new collagen, she adds. Since the potent ingredient does have some potentially irritating side-effects (redness, dryness, flaking), be sure to apply only a pea-size drop of any retinoid-containing product on your entire face. You can also try using it every other night to help minimize irritation. FYI, the "night" part is important; the sun inactivates the ingredient, so reserve these products solely for your evening regimen.
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