Potential Problems: Regulating Levels Melatonin is produced in the body and skin. The body is hard at work always sensing for concentrations of all cell messengers and chemicals that are being produced or taken up. To this point, Akridge says that he hasn't seen a study that takes into account what happens in skin to natural melatonin production when more is applied to skin. Typically, natural production of anything is regulated — which could impact results of melatonin skin care products.
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