7 Skin Care Ingredients You Should Never Mix, According to Derms

Retinol and benzoyl peroxide are both effective treatments for acne, according to Dr. Pierre, as they both work hard to unclog pores from pimple-causing bacteria.

That said, using them at the same time can spell out trouble for your skin, as doing so can cause unwanted irritation, redness, and flaking. "To avoid unwanted reactions, it's better to reserve benzoyl peroxide for the morning (be aware that it can bleach clothing!) and retinol for the evening," explains Dr. Pierre.

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