Retinoids, which are vitamin A derivates, have long been a reliable, effective treatment for acne (even before they were used for anti-aging reasons). While they're typically only available via prescription, adapalene 0.1 percent was recently made available over the counter as Differin.

"While this can be used all over for acne prevention as well as to minimize the appearance of fine lines, it can also be used as spot treatment for individual acne lesions. When treating individual lesions, I recommend applying a thicker layer," says Dr. Berliner. She adds that retinoids are notoriously irritating to the skin, but that the adapalene version is usually better tolerated. However, you can still do a few things to reduce potential irritation.

Berliner says, "The irritation is minimized when applied to dry skin, so waiting a few minutes after washing your face can be helpful. I also recommend patients use moisturizer regularly."

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Dr. Markowitz recommends this product for those who prefer using natural ingredients in their skincare. "This product features ingredients such as apple cider vinegar and peppermint, which are natural astringents. They are also non-irritating," she says. "After application let the product dry before adding any moisturizers."

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This salicylic acid in this spot treatment helps to reduce blemishes, whiteheads, and blackheads by unclogging pores via cell turnover. It also contains glycolic acid (an AHA) as well as fruit enzymes which can help even out your complexion. Dr. Garshick recommends it for sensitive skin types because it's free of alcohol, fragrances, parabens, and propylene glycol. Also, it contains aloe vera which can help soothe skin and minimize irritation.

"Although it can be used up to three times daily, it is best to start off just one to two times per day and increase the frequency only if needed, or as tolerated," she advises.

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