EGF is one of the newer ingredients in skin care which means that it hasn't been as extensively researched as others. "They are less data-proven compared to sun protection, retinoids, alpha hydroxy acids and antioxidants," says King. "But there is definitely potential. And they are less irritating compared to retinoids and alpha hydroxy acids."
Frank continues that there are some studies, but growth factors are not considered as potent as some other anti-aging superstars, like retinoids. "There are some that question their effect at all given that the molecules are considered too large to penetrate deep into skin," says Frank.
He also notes that the main concern is that growth factors could speed up production of skin cancer, but "it is unproven."
Take note: Vargas says that EGF has had a lot of very misleading and irresponsible marketing over the last few years. However, that doesn't discount the ingredient's performance. "It's highly effective and very exciting to me," she says.
The Georgia Louise Hollywood EGF Serum, $160, is used during her famous facial of the same name. It helps minimize the appearance of pores and softens fine lines and wrinkles. Besides EGF, the clean, ionizable formula also has copper to calm skin and hyaluronic acid for plumping.
Want plant-derived EGF? The Joanna Vargas Twilight Face Mask , $75, is an epidermal growth factor sheet mask made from 40 different plant and vegetable stem cells. Vargas thinks it's "the most healing thing I've put on the face," making it excellent post-sun or post-peel.
The SkinMedica TNS Essential Serum, $281, is reportedly the first topical cosmetic made almost entirely of stabilized human growth factor (93.6 percent). The dual chamber formula has the EGF in one chamber and the brand's APS Corrective Complex in the other. When pumped out, they target texture, tone and fine lines.
Bioeffect dubs itself as "the first and only skin care to invent barley EGF." Those looking for something slightly different can try the Bioeffect EGF Eye Serum, $90. The alcohol-, fragrance- and oil-free formula is suitable for all skin types and has a cooling stainless steel roller applicator.
